聚合全网优质知识内容，持续更新AI科普、编程小知识、医学健康、科学前沿、心理成长、外刊精选、设计资源与实用干货，帮助用户高效获取有价值的学习资料和知识分享。https://learn.88lin.eu.orghttps://learn.88lin.eu.org/posts/CNSmydream-1187https://learn.88lin.eu.org/posts/CNSmydream-1187Sun, 24 May 2026 23:17:45 GMT<div class="image-list-container image-list-even"> <button type="button" class="image-preview-button image-preview-wrap" popovertarget="modal-CNSmydream-1187-0" popovertargetaction="show" aria-label="Open image preview: 睾丸细胞周期新发现：Sertoli细胞可能主导精子生成节奏？男性生育能力与精子质量一直是关注焦点"> <img src="/static/https://cdn5.telesco.pe/file/HrTNEO3foaobMIzF2QLorm0Xu43J8QhEopKaNbhmhVCyVudFU77LXCy305MFDEGr1La_jqhbtos9ikGUArKawgYxUpBeqRZ95lSNLwqaXcH1cpWLpSJNZQiMDmRq93HzXHU-BIB30Cn6ugIM5I2BN6kcEAxZ1HVcn6CiFSffMEXmzO2MEdR79vbYy5CKwSBp0IrSJiWPwbD2nniwIUdP2H109JowfGIUJOnzG1tHnCLzD7aIC9z9xJbC_JPWGbDOLETgjFzTSqpRoDARiKYHJ7thvtp_QlWHmkCtImXZAG6Xo-FxZ3U3vJmRMMqPy_pUAFpyVxPR17OaAZsPWb9YIg.jpg" alt="睾丸细胞周期新发现：Sertoli细胞可能主导精子生成节奏？男性生育能力与精子质量一直是关注焦点" width="277" height="172" loading="eager" /> </button> <div class="modal" id="modal-CNSmydream-1187-0" popover="auto" aria-label="Image preview"> <button type="button" class="modal__backdrop" popovertarget="modal-CNSmydream-1187-0" popovertargetaction="hide" aria-label="Close image preview"></button> <button type="button" class="modal__close" popovertarget="modal-CNSmydream-1187-0" popovertargetaction="hide" aria-label="Close image preview">×</button> <div class="modal__surface"> </div> </div> <button type="button" class="image-preview-button image-preview-wrap" popovertarget="modal-CNSmydream-1187-1" popovertargetaction="show" aria-label="Open image preview: 睾丸细胞周期新发现：Sertoli细胞可能主导精子生成节奏？男性生育能力与精子质量一直是关注焦点"> <img src="/static/https://cdn5.telesco.pe/file/ZpEolE03UPpdukS3TOLDAdGVmayS92CVayDHJzrMREa5X5abICaoaEYd8RRxVJNd_qmPVP0frqnFzyVS6cet3bE2dO9LH1imx-mB76gtRwUPpBwx6c_99gJ-Qe_7hwQK3ssWZt_glik4_Nm8CSJ_jVraY3DIFzYPfk0RDehRoHyIg7lxyoJZ_Dmgsy7Ri39B2sAEg18Lgi5Cv8cWApA1iMVfbDIep3VQ41gzmbIjXEfzozhUKha_nBMJp6rM6qMP4TdaWmLLahXhmU_zjYAwtkZcdQQNRJuxBDObf-06PzSbzzMphyBXVNiyL3mtoNkRC-U9tVpBH6KNvXbLmzZ0eQ.jpg" alt="睾丸细胞周期新发现：Sertoli细胞可能主导精子生成节奏？男性生育能力与精子质量一直是关注焦点" width="174" height="172" loading="eager" /> </button> <div class="modal" id="modal-CNSmydream-1187-1" popover="auto" aria-label="Image preview"> <button type="button" class="modal__backdrop" popovertarget="modal-CNSmydream-1187-1" popovertargetaction="hide" aria-label="Close image preview"></button> <button type="button" class="modal__close" popovertarget="modal-CNSmydream-1187-1" popovertargetaction="hide" aria-label="Close image preview">×</button> <div class="modal__surface"> </div> </div> </div><div class="tgme_widget_message_text js-message_text"><b>睾丸细胞周期新发现：Sertoli细胞可能主导精子生成节奏？</b><br /><br />男性生育能力与精子质量一直是关注焦点。一项新研究揭示了睾丸内细胞周期的新机制，可能为理解精子生成提供关键线索。<br /><br />科学家们利用空间转录组学技术，对小鼠睾丸细胞进行了高分辨率分析，发现支持细胞（<mark class="highlight">Sertoli细胞</mark>）具有周期性转录模式，与精子生成过程同步。即使在去除生殖细胞后，Sertoli细胞的这种周期性依然存在，但幅度和相位有所变化，表明其周期性具有内在特性。研究还发现，维生素A酸（RA）作为关键信号，能调控Sertoli细胞的周期，而Wnt信号则影响其周期性。这提示Sertoli细胞可能作为“主控者”，通过周期性活动维持精子生成的节奏。<br /><br />意义方面，这一发现挑战了传统观点，即精子生成完全由生殖细胞驱动。相反，支持细胞可能通过内在周期性为精子生成提供基础框架，而生殖细胞信号则进一步精细调节。不过，研究目前仅在老鼠模型中进行，人类睾丸的机制可能存在差异，未来需要更多研究来验证这一模型。<br /><br /><blockquote>看来精子生成不是“单打独斗”，Sertoli细胞才是幕后大Boss？<i class="emoji"><b>🧪</b></i></blockquote><br /><br />来源：<a href="https://doi.org/10.1016/j.cell.2026.04.036" target="_blank" rel="noopener" title="Cell">Cell</a><br /><br /><a href="/search/result?q=%23%E7%9D%BE%E4%B8%B8" title="#睾丸">#睾丸</a> <a href="/search/result?q=%23%E7%B2%BE%E5%AD%90%E7%94%9F%E6%88%90" title="#精子生成">#精子生成</a> <a href="/search/result?q=%23%E7%A9%BA%E9%97%B4%E8%BD%AC%E5%BD%95%E7%BB%84%E5%AD%A6" title="#空间转录组学">#空间转录组学</a> <a href="/search/result?q=%23Sertoli%E7%BB%86%E8%83%9E" title="#Sertoli细胞">#Sertoli细胞</a> <a href="/search/result?q=%23%E7%BB%B4%E7%94%9F%E7%B4%A0A%E9%85%B8" title="#维生素A酸">#维生素A酸</a> <a href="/search/result?q=%23Wnt%E4%BF%A1%E5%8F%B7" title="#Wnt信号">#Wnt信号</a><br /><br /><i class="emoji"><b>🧬</b></i> <a href="https://t.me/CNSmydream" target="_blank" rel="noopener" title="频道">频道</a> ｜ <i class="emoji"><b>🧑‍🔬</b></i> <a href="https://t.me/CNSmydream2" target="_blank" rel="noopener" title="群组">群组</a> ｜ <i class="emoji"><b>📨</b></i> <a href="https://t.me/sciReviewer_bot" target="_blank" rel="noopener" title="投稿">投稿</a></div>