聚合全网优质知识内容，持续更新AI科普、编程小知识、医学健康、科学前沿、心理成长、外刊精选、设计资源与实用干货，帮助用户高效获取有价值的学习资料和知识分享。https://learn.88lin.eu.orghttps://learn.88lin.eu.org/posts/CNSmydream-1135https://learn.88lin.eu.org/posts/CNSmydream-1135Mon, 04 May 2026 23:14:00 GMT<div class="image-list-container image-list-even"> <button type="button" class="image-preview-button image-preview-wrap" popovertarget="modal-CNSmydream-1135-0" popovertargetaction="show" aria-label="Open image preview: 肿瘤周围的脂肪组织，竟在暗中“帮助”癌症逃避免疫攻击？免疫检查点抑制剂（如PD-1抗体）在癌症治疗中效果有限，部分原因在于肿瘤微环境中存在免疫逃逸机制"> <img src="/static/https://cdn5.telesco.pe/file/mnTjzyG8QyDQMJuntAgFBVFu_4TME1P6b7GtMNDNL3QWbtwVSrhX6eQ9cnNIPmCkyGoumDCHZ4ie12mpk2UuXZFSJ3_arq6JSx_NQuV1DoRDHELKau1AzF0D3Gmz_flalbhIGXeeUuyu8DFpr2tWwcQc9Y-xE5DHFpWex5neuoCdW03GsQAuYcb-6mYWIGuis_pg_vzo_WGeDpG4duKi-g5s4NIWwaHPb01_97NNrYibBALIgcAW6AfYnFRAsJi535-Rv1ErNZ2bv2utvHuTJUGpdJrUAO7PhzSrA1qdKBrPLTXdxluOO4QuRTtO6WtXQ9Rs27zT31xO7nbEojsplQ.jpg" alt="肿瘤周围的脂肪组织，竟在暗中“帮助”癌症逃避免疫攻击？免疫检查点抑制剂（如PD-1抗体）在癌症治疗中效果有限，部分原因在于肿瘤微环境中存在免疫逃逸机制" width="453" height="239" loading="eager" /> </button> <div class="modal" id="modal-CNSmydream-1135-0" popover="auto" aria-label="Image preview"> <button type="button" class="modal__backdrop" popovertarget="modal-CNSmydream-1135-0" popovertargetaction="hide" aria-label="Close image preview"></button> <button type="button" class="modal__close" popovertarget="modal-CNSmydream-1135-0" popovertargetaction="hide" aria-label="Close image preview">×</button> <div class="modal__surface"> </div> </div> <button type="button" class="image-preview-button image-preview-wrap" popovertarget="modal-CNSmydream-1135-1" popovertargetaction="show" aria-label="Open image preview: 肿瘤周围的脂肪组织，竟在暗中“帮助”癌症逃避免疫攻击？免疫检查点抑制剂（如PD-1抗体）在癌症治疗中效果有限，部分原因在于肿瘤微环境中存在免疫逃逸机制"> <img src="/static/https://cdn5.telesco.pe/file/qOuDBMFnfYG6fgbxvArzxw40_NuHmQzmPt1sP74dd_qfraU4RB7-hByIdS7FmBPjcBKFROdaGwksgoco-Q26dkj-4nZGa8OSaSF9cx8Gn6trDIUuxuDcohNcfMxZGFeqgc-DHjSnjgTS0iD6BanYCLSIaVs1tOcwhC5hzXgomWdLUzw_df6b-IvzooQa11Q5K_e5vHwxQb2fGGNQfsRBOot6Q9LJBp08h5RHXYRYPkDkTQ7ELbjcQUhPH7Lir5E56U3DNaMhbBTF_AAucQZEPwZ1y9PIRNBGX3pBfTom1MWivSXfem8e8LqB2Qq4hsPDvpEmdxMetJgGKRAXvSQabA.jpg" alt="肿瘤周围的脂肪组织，竟在暗中“帮助”癌症逃避免疫攻击？免疫检查点抑制剂（如PD-1抗体）在癌症治疗中效果有限，部分原因在于肿瘤微环境中存在免疫逃逸机制" width="136" height="170" loading="eager" /> </button> <div class="modal" id="modal-CNSmydream-1135-1" popover="auto" aria-label="Image preview"> <button type="button" class="modal__backdrop" popovertarget="modal-CNSmydream-1135-1" popovertargetaction="hide" aria-label="Close image preview"></button> <button type="button" class="modal__close" popovertarget="modal-CNSmydream-1135-1" popovertargetaction="hide" aria-label="Close image preview">×</button> <div class="modal__surface"> </div> </div> <button type="button" class="image-preview-button image-preview-wrap" popovertarget="modal-CNSmydream-1135-2" popovertargetaction="show" aria-label="Open image preview: 肿瘤周围的脂肪组织，竟在暗中“帮助”癌症逃避免疫攻击？免疫检查点抑制剂（如PD-1抗体）在癌症治疗中效果有限，部分原因在于肿瘤微环境中存在免疫逃逸机制"> <img src="/static/https://cdn5.telesco.pe/file/O3wQSehNOSnah-LpOeOjr-akSyttSZaS_zkRRhJojGXqW4QpNzNvmthWc_G5J0msQEg3Oh9YT1Zl6o3F6BeyokzHzRLoesEfNgxOpOcos8fhw4zr-Z6N5dDRZ8YqBoC1vYAtEuA6czd_b_1wb2tmmfDm35m5cHFbCsFzH1-finGlOdKMFrcW3OTamfiza3t3eIVfoHnG1rs9hA_KQACi5jFpU9aK_OsisUhE4oX6sVXgPQz9afs3PG2bAHDXypmJjFPyucbE60lpkrwseR78XtWuSp_MhEIkwsLwGV7dtlopkDl_ZXN1ij_3QZKDuck7nS-VUlU_bMXyFdtf3kqrLw.jpg" alt="肿瘤周围的脂肪组织，竟在暗中“帮助”癌症逃避免疫攻击？免疫检查点抑制剂（如PD-1抗体）在癌症治疗中效果有限，部分原因在于肿瘤微环境中存在免疫逃逸机制" width="176" height="170" loading="eager" /> </button> <div class="modal" id="modal-CNSmydream-1135-2" popover="auto" aria-label="Image preview"> <button type="button" class="modal__backdrop" popovertarget="modal-CNSmydream-1135-2" popovertargetaction="hide" aria-label="Close image preview"></button> <button type="button" class="modal__close" popovertarget="modal-CNSmydream-1135-2" popovertargetaction="hide" aria-label="Close image preview">×</button> <div class="modal__surface"> </div> </div> <button type="button" class="image-preview-button image-preview-wrap" popovertarget="modal-CNSmydream-1135-3" popovertargetaction="show" aria-label="Open image preview: 肿瘤周围的脂肪组织，竟在暗中“帮助”癌症逃避免疫攻击？免疫检查点抑制剂（如PD-1抗体）在癌症治疗中效果有限，部分原因在于肿瘤微环境中存在免疫逃逸机制"> <img src="/static/https://cdn5.telesco.pe/file/qTvqyvS-hsc7VxuadG2jpyvrUCsVJPcojcG0yHSG1u4e3X4dsL6Z6viC0Z0qZf8t3adF2VazA3ceZY8otPc8I660aRMwzaCvX1-M0ZJWwAwXDS-6lTE4n9MKDKtufw7if8Hk6469Pi7Rs6j3uxnJVMpIvQg99NzFF2P9U2UuTQpNyw2Y4BXI7NbOTI4OT89Hc1zK0xDuRgVmyrdnwUNDwPb_2VkYEmPxw83Dbg00SzPMBE1M34YzTPoHVBeA6-mlv8FrfuaCQTPC950GhV1RbJjFnLSN3BbiKEWQ9madtZJpEH3rPFTMH7_dedhc0m9y-5zTnMHz7hD5h2wpEeoRNw.jpg" alt="肿瘤周围的脂肪组织，竟在暗中“帮助”癌症逃避免疫攻击？免疫检查点抑制剂（如PD-1抗体）在癌症治疗中效果有限，部分原因在于肿瘤微环境中存在免疫逃逸机制" width="137" height="170" loading="eager" /> </button> <div class="modal" id="modal-CNSmydream-1135-3" popover="auto" aria-label="Image preview"> <button type="button" class="modal__backdrop" popovertarget="modal-CNSmydream-1135-3" popovertargetaction="hide" aria-label="Close image preview"></button> <button type="button" class="modal__close" popovertarget="modal-CNSmydream-1135-3" popovertargetaction="hide" aria-label="Close image preview">×</button> <div class="modal__surface"> </div> </div> </div><div class="tgme_widget_message_text js-message_text"><b>肿瘤周围的脂肪组织，竟在暗中“帮助”癌症逃避免疫攻击？</b><br /><br />免疫检查点抑制剂（如PD-1抗体）在癌症治疗中效果有限，部分原因在于肿瘤微环境中存在免疫逃逸机制。一项新研究揭示，肿瘤周围的脂肪组织（tVAT）可能扮演关键角色，它不仅与肿瘤紧密相邻，还通过独特机制促进癌症逃避免疫攻击。<br /><br />研究通过单细胞RNA分析发现，tVAT微环境中富含淋巴细胞，特别是肿瘤特异性CD8+ T细胞，但脂肪组织通过激活CXCL12-CXCR4信号轴，竞争这些免疫细胞，帮助肿瘤躲避攻击。更关键的是，肿瘤分泌的因子诱导脂肪干细胞转化为成纤维细胞，后者大量分泌CXCL12，进一步加剧免疫逃逸。这种“脂肪-间充质转化”过程为肿瘤提供了保护屏障。<br /><br />该发现为癌症免疫治疗提供了新靶点，靶向tVAT可能增强PD-1等免疫检查点抑制剂的效果。不过，研究基于患者样本，未来需要更多实验验证，并探索具体干预策略，以避免对正常脂肪组织造成损伤。<br /><br /><blockquote>脂肪也能“叛变”？癌症治疗又多了一层新思路 <i class="emoji"><b>🤯</b></i></blockquote><br /><br />来源：<a href="https://doi.org/10.1038/s41556-026-01885-0" target="_blank" rel="noopener" title="Nature cell biology">Nature cell biology</a><br /><br /><a href="/search/result?q=%23%E7%BB%93%E7%9B%B4%E8%82%A0%E7%99%8C" title="#结直肠癌">#结直肠癌</a> <a href="/search/result?q=%23%E5%85%8D%E7%96%AB%E9%80%83%E9%80%B8" title="#免疫逃逸">#免疫逃逸</a> <a href="/search/result?q=%23%E8%84%82%E8%82%AA%E7%BB%84%E7%BB%87" title="#脂肪组织">#脂肪组织</a> <a href="/search/result?q=%23%E5%85%8D%E7%96%AB%E6%B2%BB%E7%96%97" title="#免疫治疗">#免疫治疗</a> <a href="/search/result?q=%23%E8%84%82%E8%82%AA%E9%97%B4%E5%85%85%E8%B4%A8%E8%BD%AC%E5%8C%96" title="#脂肪间充质转化">#脂肪间充质转化</a><br /><br /><i class="emoji"><b>🧬</b></i> <a href="https://t.me/CNSmydream" target="_blank" rel="noopener" title="频道">频道</a> ｜ <i class="emoji"><b>🧑‍🔬</b></i> <a href="https://t.me/CNSmydream2" target="_blank" rel="noopener" title="群组">群组</a> ｜ <i class="emoji"><b>📨</b></i> <a 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